Publications
Can targeted nanoparticles distinguish cancer metastasis from inflammation?
A.S. Choi, T.J. Moon, W. Abuhashim, A. Bhalotia, H. Qian, K.E. Paulsen, M. Lorkowski, C. Ndamira, R. Gopalakrishnan, A. Krishnamurthy, W. P. Schiemann, E. Karathanasis. Journal of Controlled Release (2023) doi: 10.1016/j.jconrel.2023.03.054 | PubMed
Dual agonist immunostimulatory nanoparticles combine with PD1 blockade for curative neoadjuvant immunotherapy of aggressive cancers
P.U. Atukorale, T.J. Moon, A.R. Bokatch, C.F. Lusi, J.T. Routhier, V.J. Deng, E. Karathanasis. Nanoscale 14 (2022) 1144-1159 | PubMed
Comparison of the uptake of untargeted and targeted immunostimulatory nanoparticles by immune cells in the microevnironment of metastatic breast cancer
G. Covarrubias, T.J. Moon, G. Loutrianakis, H.M. Sims, M.P. Umapathy, M.E. Lorkowski, , P.A. Bielecki, M.L. Wiese, P.U. Atukorale, E. Karathanasis. Journal of Materials Chemistry B 10 (2022) 224-235 | PubMed
Hyperthermia-mediated changes in the tumor immune microenvironment using iron oxide nanoparticles
G. Covarrubias, M.E. Lorkowski, H.M. Sims, G. Loutrianakis, A. Rahmy, A. Cha, E. Abenojar, S. Wickramasinghe, T.J. Moon, A.C.S. Samia, E. Karathanasis. Nanoscale Advances 3 (2021) 5890-5899 | PubMed
Stimuli-responsive iron oxide nano-theranostics: A versatile and powerful approach for cancer therapy
M. Lorkowski, P. Atukorale, K. Ghaghada, E. Karathanasis. Advanced Healthcare Materials 10 (2021) e2001044 | PubMed
Immunostimulatory silica nanoparticle activates the innate immune system of brain tumors
P.A. Bielecki, M.E. Lorkowski, W.M. Becicka, P.U. Atukorale, T.J. Moon, Y. Zhang, M. Wiese, G. Covarrubias, S. Ravichandran, E. Karathanasis. Nanoscale Horizons 6 (2021) 156-167 | PubMed
Immunostimulatory nanoparticle incorporating two immune agonists for the treatment of pancreatic tumors
M.E. Lorkowski, P.U. Atukorale, P.A. Bielecki, K.H. Tong, G. Covarrubias, Y. Zhang, G. Loutrianakis, T.J. Moon, A.R. Santulli, W.M. Becicka, E. Karathanasis. Journal of Controlled Release 330 (2021) 1095–1105 | PubMed
The effect of PEGylation on the efficacy and uptake of an immunostimulatory nanoparticle in the tumor immune microenvironment
W.M. Becicka, P.A. Bielecki, M.E. Lorkowski, T.J. Moon, Y. Zhang, P.U. Atukorale, G. Covarrubias, E. Karathanasis. Nanoscale Advances 3 (2021) 4961-4972 | PubMed
Chronic neural activity recorded within breast tumors
G.A. McCallum, J. Shiralkar, D. Suciu, G. Covarrubias, J.S. Yu, E. Karathanasis, D.M. Durand. Scientific Reports 10 (2020) 14824 | PubMed
PTPmu-targeted nanoparticles label invasive pediatric and adult glioblastoma
G. Covarrubias, M.L. Johansen, J. Vincent, B.O. Erokwu, S.E. Craig, A. Rahmy, A. Cha, M. Lorkowski, C. MacAskill, B. Scott, M. Gargesha, D. Roy, C.A. Flask, E. Karathanasis, S.M. Brady-Kalnay. Nanomedicine: Nanotechnology, Biology, and Medicine 28 (2020) 102216 | PubMed | *cover and feature article
Nanoparticle encapsulation of synergistic immune agonists enables systemic co-delivery to tumor sites and interferon β-driven anti-tumor immunity
P.U. Atukorale, S. Raghunathan, V. Raguveer, T.J. Moon, C. Zhang, P. Bielecki, M.L. Wiese, A.L. Goldberg, G. Covarrubias, C.J. Hoimes, E. Karathanasis. Cancer Research 79 (2019) 5394-5406 | PubMed
Treatment of brain tumors using multicomponent silica nanoparticles
O. Turan, P. Bielecki, V.S. Perera, M. Lorkowski, G. Covarrubias, K. Tong, A. Yun, G. Loutrianakis, S. Raghunathan, Y. Park, T. Moon, S. Cooley, D. Dixit, M.A. Griswold, K.B. Ghaghada, P.M. Peiris, J.N. Rich, E. Karathanasis. Advanced Therapeutics 2 (2019) 1900118 | PubMed
The effect of dose and selection of two different ligands on the deposition of targeted nanoparticles in brain tumors
O. Turan, P. Bielecki, K. Tong, G. Covarrubias, T. Moon, A. Rahmy, S. Cooley, Y. Park, P.M. Peiris, K.B Ghaghada, E. Karathanasis. Molecular Pharmaceutics 16(10) (2019) 4352-4360 | PubMed
Effective treatment of cancer metastasis using a dual-ligand nanoparticle
G. Covarrubias, F. He, S. Raghunathan, O. Turan, P.M. Peiris, W.P. Schiemann, E. Karathanasis. PLoS ONE 14(7) (2019) e0220474 | PubMed
Delivery of drugs into brain tumors using multicomponent silica nanoparticle
O. Turan, P. Bielecki, V.S. Perera, M. Lorskowski, G. Covarrubias, K. Tong, A. Yun, A. Rahmy, T. Ouyang, S. Raghunathan, R. Gopalakrishnan, M.A. Griswold, K.B Ghaghada, P.M. Peiris, E. Karathanasis. Nanoscale 11 (2019) 11910-11921 | PubMed
Imaging breast cancer metastasis using a dual-ligand nanochain particle
G. Covarrubias, A. Cha, A. Rahmy, M. Lorkowski, V. Perera, B.O. Erokwo, C. Flask, P.M. Peiris, W.P. Schiemann, E. Karathanasis. PLoS ONE 13(10) (2018) e0204296 | PubMed
Precise targeting of cancer metastasis using multi-ligand nanoparticles incorporating four different ligands
P.M. Peiris, F. He, G. Covarrubias, S. Raghunathan, O. Turan, M. Lorkowski, B. Gnanasambandam, C. Wu, W.P. Schiemann, E. Karathanasis. Nanoscale 10 (2018) 6861-6871 | PubMed
It's getting hot in there: Targeting cancer stem-like cells with hyperthermia
H. Huang, K. Yu, A. Mohammadi, E. Karathanasis, A. Godley, J.S. Yu. Journal of Stem Cell and Transplantation Biology 2(2) (2017) 113-120 | PubMed
One-pot synthesis of nanochain particles for targeting brain tumors
V.S. Perera, G. Covarrubias, M. Lorkowski, P. Atukorale, A. Rao, S. Raghunathan, R. Gopalakrishnan, B.O Erokwu, Y. Liu, D. Dixit, S.M. Brady-Kalnay, D. Wilson, C. Flask, J. Rich, P.M. Peiris, E. Karathanasis. Nanoscale 9 (2017) 9659-9667 | PubMed
Vascular targeting of nanoparticles for molecular imaging of diseased endothelium
P.U. Atukorale, G. Covarrubias, L. Bauer, E. Karathanasis. Advanced Drug Delivery Reviews 113 (2017) 141-156 | PubMed
Crossing the barrier: Treatment of brain tumors using nanochain particles
K.B. Ghaghada, E. Karathanasis. WIREs Nanomedicine & Nanobiotechnology 8 (2016) 678-695 | PubMed
Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis
E. Doolittle, P.M. Peiris, G. Doron, A. Goldberg, S. Tucci, S. Rao, S. Shah, M. Sylvestre, P. Govender, O. Turan, W.P. Schiemann, Z. Lee, E. Karathanasis. ACS Nano 9(8) (2015) 8012-8021 | PubMed
Vascular targeting of a gold nanoparticle to breast cancer metastasis
P.M. Peiris, P. Deb, E. Doolittle, G. Doron, A. Goldberg, P. Govender, S. Shah, S. Rao, S. Carbone, T. Cotey, M. Sylvestre, S. Singh, W.P. Schiemann, Z. Lee, E. Karathanasis. Journal of Pharmaceutical Sciences 104(8) (2015) 2600-2610 | PubMed
Treatment of invasive brain tumors using a chain-like nanoparticle
P.M. Peiris, A. Abramowski, J. Mcginnity, E. Doolittle, R. Toy, R. Gopalakrishnan, S. Shah, L. Bauer, K.B. Ghaghada, C. Hoimes, S. Brady-Kalnay, J.P. Basilion, M.A. Griswold, E. Karathanasis. Cancer Research 75(7) (2015) 1356–1365 | PubMed
Targeted nanotechnology for cancer imaging
R. Toy, L. Bauer, C. Hoimes, K.B. Ghaghada, E. Karathanasis. Advanced Drug Delivery Reviews 76 (2014) 79-97 | PubMed
Shaping cancer nanomedicine: The effect of particle shape on the in vivo journey of nanoparticles
R. Toy, P.M. Peiris, K.B. Ghaghada, E. Karathanasis. Nanomedicine (Lond) 9(1) (2014) 121-134 | PubMed
Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle
P.M. Peiris, R. Toy, A. Abramowski, P. Vicente, S. Tucci, L. Bauer, A. Mayer, M. Tam, E. Doolittle, J. Pansky, E. Tran, D. Lin, W.P. Schiemann, K.B. Ghaghada, M.A. Griswold, E. Karathanasis. Journal of Controlled Release 173 (2014) 51-59 | PubMed | *cover and featured article
On-command drug release from nanochains inhibits growth of breast tumors
P.M. Peiris, M. Tam, P. Vicente, A. Abramowski, R. Toy, L. Bauer, A. Mayer, J. Pansky, E. Doolittle, S. Tucci, E. Schmidt, C. Shoup, S. Rao, K. Murray, R. Gopalakrishnan, R.A. Keri, J.P. Basilion, M.A. Griswold, E. Karathanasis. Pharmaceutical Research 31(6) (2014) 1460-1468 | PubMed
Multimodal in vivo imaging exposes the voyage of nanoparticles in tumor microcirculation
R. Toy, E. Hayden, A. Camann, Z. Berman, P. Vicente, E. Tran, J. Meyers, J. Pansky, P. Peiris, H. Wu, A. Exner, D. Wilson, K. Ghaghada, E. Karathanasis. ACS Nano 7(4) (2013) 3118-3129 | PubMed
Enhanced delivery of Chemotherapy to tumors using a multi-component nanochain with radiofrequency-tunable drug release
P. Peiris, L. Bauer, R. Toy, E. Tran, J. Pansky, E. Doolittle, E. Schmidt, E. Hayden, A. Mayer, R. Keri, M. Griswold, E. Karathanasis. ACS Nano 6(5) (2012) 4157-4168 | PubMed
Imaging metastasis using an integrin-targeting chain-shaped nanoparticle
P. Peiris, R. Toy, E. Doolittle, J. Pansky, A. Abramowski, M. Tam, P. Vicente, E. Tran, E. Hayden, A. Camann, A. Mayer, B. Erokwu, Z. Berman, D. Wilson, H. Baskaran, C. Flask, R. Keri, E. Karathanasis. ACS Nano 6(10) (2012) 8783-8795 | PubMed
High-resolution CT vascular imaging using blood pool contrast agents
A.V. Annapragada, E. Hoffman, A. Divekar, E. Karathanasis, K.B. Ghaghada. Methodist Debakey Cardiovasc J 8(1) (2012) 18-22 | PubMed
The effects of particle size, shape and density on margination of nanoparticles in microcirculation
R. Toy, E. Hayden, C. Shoup, H. Baskaran, E. Karathanasis. Nanotechnology 22(2011) 115101 (9pp) | PubMed
Is nanomedicine still promising?
P.M. Peiris, E. Karathanasis. Oncotarget 2(6) (2011) 430-432 | PubMed
Assembly of linear nano-chains from nanospheres with asymmetric surface chemistry
P.M. Peiris, E. Schmidt, M. Calabrese, E. Karathanasis. PLoS ONE 6(1) (2011) e15927 | PubMed
Selective targeting of nanocarriers to neutrophils and monocytes
E. Karathanasis, C.M. Geigerman, C.A. Parkos, L. Chan, R.V. Bellamkonda, D.L. Jaye. Annals of Biomedical Engineering 37(10) (2009) 1984-1992 | PubMed
Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers
E. Karathanasis, L. Chan, L. Karumbaiah, , K. McNeeley, C.J. D'Orsi, A.V. Annapragada, I. Sechopoulos, R.V. Bellamkonda. PLoS ONE 4(6) (2009) e5843 | PubMed
Masking and triggered umasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors
K. McNeeley, E. Karathanasis, A.V. Annapragada, R.V. Bellamkonda. Biomaterials (2009) 30(23-24) 3986-3995 | PubMed
Imaging nanoprobe for prediction of nanoparticle chemotherapy using mammography
E. Karathanasis, S. Suryanarayanan, S.R. Balusu, K. McNeeley, I. Sechopoulos, A. Karellas, A.V. Annapragada, R.V. Bellamkonda. Radiology 250(2) (2009) 398-406 | PubMed
MRI mediated, non-invasive tracking of intratumoral distribution of nanocarriers in rat glioma
E. Karathanasis, J. Park, A. Agarwal, V. Patel, F. Zhao, A.V. Annapragada, X. Hu, R.V. Bellamkonda. Nanotechnology 19 315101 (9pp) 2008 | PubMed
Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy
E. Karathanasis, L. Chan, S.R. Balusu, C.J. D?Orsi, A.V. Annapragada, I. Sechopoulos, R.V. Bellamkonda. Biomaterials 29(36) (2008) 4815-4822 | PubMed
Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats
E. Karathanasis, R. Bhavane, A.V. Annapragada. International Journal of Nanomedicine 2(3) (2007) 501-513 | PubMed
Triggered release of ciprofloxacin from nanostructured agglomerated vesicles
R. Bhavane, E. Karathanasis, A.V. Annapragada. International Journal of Nanomedicine 2(3) (2007) 407-418 | PubMed
Triggered release of inhaled insulin from the agglomerated vesicles: Pharmacodynamic studies in rats
E. Karathanasis, R. Bhavane, A.V. Annapragada. Journal of Controlled Release 113(2) (2006) 117-127 | PubMed
Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery
E. Karathanasis, A. Ayyagari, R. Bhavane, R. Bellamkonda, A.V. Annapragada. Journal of Controlled Release 103(1) (2005) 159-175 | PubMed
Agglomerated Vesicle Technology: A new class of particles for controlled and modulated pulmonary drug delivery
R. Bhavane, E. Karathanasis, A.V. Annapragada. Journal of Controlled Release 93(1) (2003) 15-28 | PubMed
