Flexible Multifunctional Titania Nanotube Array Platform for Biological Interfacing

H.A. Hamedani, T. Stegall, Y. Yang, H. Wang, A. Menon, A. Bhalotia, E. Karathanasis, J.R. Capadona, A. Hess-Dunning. MRS Bulletin (2023) doi:10.1557/s43577-023-00628-y 

Can targeted nanoparticles distinguish cancer metastasis from inflammation? 

A.S. Choi, T.J. Moon, W. Abuhashim, A. Bhalotia, H. Qian, K.E. Paulsen, M. Lorkowski, C. Ndamira, R. Gopalakrishnan, A. Krishnamurthy, W. P. Schiemann, E. Karathanasis. Journal of Controlled Release 362 (2023) 812-819 | PubMed

Dual agonist immunostimulatory nanoparticles combine with PD1 blockade for curative neoadjuvant immunotherapy of aggressive cancers

P.U. Atukorale, T.J. Moon, A.R. Bokatch, C.F. Lusi, J.T. Routhier, V.J. Deng, E. Karathanasis. Nanoscale 14 (2022) 1144-1159 | PubMed

Comparison of the uptake of untargeted and targeted immunostimulatory nanoparticles by immune cells in the microevnironment of metastatic breast cancer

G. Covarrubias, T.J. Moon, G. Loutrianakis, H.M. Sims, M.P. Umapathy, M.E. Lorkowski, , P.A. Bielecki, M.L. Wiese, P.U. Atukorale, E. Karathanasis. Journal of Materials Chemistry B 10 (2022) 224-235 | PubMed

Hyperthermia-mediated changes in the tumor immune microenvironment using iron oxide nanoparticles

G. Covarrubias, M.E. Lorkowski, H.M. Sims, G. Loutrianakis, A. Rahmy, A. Cha, E. Abenojar, S. Wickramasinghe, T.J. Moon, A.C.S. Samia, E. Karathanasis. Nanoscale Advances 3 (2021) 5890-5899 | PubMed

Stimuli-responsive iron oxide nano-theranostics: A versatile and powerful approach for cancer therapy

M. Lorkowski, P. Atukorale, K. Ghaghada, E. Karathanasis. Advanced Healthcare Materials 10 (2021) e2001044 | PubMed

Immunostimulatory silica nanoparticle activates the innate immune system of brain tumors

P.A. Bielecki, M.E. Lorkowski, W.M. Becicka,  P.U. Atukorale,  T.J. Moon,  Y. Zhang,  M. Wiese,  G. Covarrubias, S. Ravichandran, E. Karathanasis.  Nanoscale Horizons 6 (2021) 156-167 | PubMed

Immunostimulatory nanoparticle incorporating two immune agonists for the treatment of pancreatic tumors

M.E. Lorkowski, P.U. Atukorale, P.A. Bielecki, K.H. Tong, G. Covarrubias, Y. Zhang, G. Loutrianakis, T.J. Moon, A.R. Santulli, W.M. Becicka, E. Karathanasis. Journal of Controlled Release 330 (2021) 1095–1105 | PubMed

The effect of PEGylation on the efficacy and uptake of an immunostimulatory nanoparticle in the tumor immune microenvironment

W.M. Becicka, P.A. Bielecki, M.E. Lorkowski, T.J. Moon, Y. Zhang,  P.U. Atukorale, G. Covarrubias, E. Karathanasis. Nanoscale Advances 3 (2021) 4961-4972 | PubMed

Chronic neural activity recorded within breast tumors

G.A. McCallum, J. Shiralkar, D. Suciu, G. Covarrubias, J.S. Yu, E. Karathanasis, D.M. Durand. Scientific Reports 10 (2020) 14824 | PubMed

PTPmu-targeted nanoparticles label invasive pediatric and adult glioblastoma

G. Covarrubias, M.L. Johansen, J. Vincent, B.O. Erokwu, S.E. Craig, A. Rahmy, A. Cha, M. Lorkowski, C.  MacAskill, B.  Scott, M. Gargesha, D. Roy, C.A. Flask, E. Karathanasis, S.M. Brady-Kalnay. Nanomedicine: Nanotechnology, Biology, and Medicine 28 (2020) 102216 | PubMed | *cover and feature article

Nanoparticle encapsulation of synergistic immune agonists enables systemic co-delivery to tumor sites and interferon β-driven anti-tumor immunity

P.U. Atukorale, S. Raghunathan, V. Raguveer, T.J. Moon, C. Zhang, P. Bielecki, M.L. Wiese, A.L. Goldberg, G. Covarrubias, C.J. Hoimes, E. Karathanasis. Cancer Research 79 (2019) 5394-5406 | PubMed

Treatment of brain tumors using multicomponent silica nanoparticles

O. Turan, P. Bielecki, V.S. Perera, M. Lorkowski, G. Covarrubias, K. Tong, A. Yun, G. Loutrianakis, S. Raghunathan, Y. Park, T. Moon, S. Cooley, D. Dixit, M.A. Griswold, K.B. Ghaghada, P.M. Peiris, J.N. Rich, E. Karathanasis. Advanced Therapeutics 2 (2019) 1900118 | PubMed

The effect of dose and selection of two different ligands on the deposition of targeted nanoparticles in brain tumors

O. Turan, P. Bielecki, K. Tong, G. Covarrubias,  T. Moon, A. Rahmy, S. Cooley, Y. Park, P.M. Peiris, K.B Ghaghada, E. Karathanasis. Molecular Pharmaceutics 16(10) (2019) 4352-4360 | PubMed

Effective treatment of cancer metastasis using a dual-ligand nanoparticle

G. Covarrubias, F. He, S. Raghunathan, O. Turan, P.M. Peiris, W.P. Schiemann, E. Karathanasis. PLoS ONE 14(7) (2019) e0220474 | PubMed

Delivery of drugs into brain tumors using multicomponent silica nanoparticle

O. Turan, P. Bielecki, V.S. Perera, M. Lorskowski, G. Covarrubias, K. Tong, A. Yun, A. Rahmy, T. Ouyang, S. Raghunathan, R. Gopalakrishnan, M.A. Griswold, K.B Ghaghada, P.M. Peiris, E. Karathanasis. Nanoscale 11 (2019) 11910-11921 | PubMed

Imaging breast cancer metastasis using a dual-ligand nanochain particle 

G. Covarrubias, A. Cha, A. Rahmy, M. Lorkowski, V. Perera, B.O. Erokwo, C. Flask, P.M. Peiris, W.P. Schiemann, E. Karathanasis. PLoS ONE 13(10) (2018) e0204296 | PubMed  

Precise targeting of cancer metastasis using multi-ligand nanoparticles incorporating four different ligands 

P.M. Peiris, F. He, G. Covarrubias, S. Raghunathan, O. Turan, M. Lorkowski, B. Gnanasambandam, C. Wu, W.P. Schiemann, E. Karathanasis. Nanoscale 10 (2018) 6861-6871 | PubMed  

It's getting hot in there: Targeting cancer stem-like cells with hyperthermia 

H. Huang, K. Yu, A. Mohammadi, E. Karathanasis, A. Godley, J.S. Yu. Journal of Stem Cell and Transplantation Biology 2(2) (2017) 113-120 | PubMed        

One-pot synthesis of nanochain particles for targeting brain tumors

V.S. Perera, G. Covarrubias, M. Lorkowski, P. Atukorale, A. Rao, S. Raghunathan, R. Gopalakrishnan, B.O Erokwu, Y. Liu, D. Dixit, S.M. Brady-Kalnay, D. Wilson, C. Flask, J. Rich, P.M. Peiris, E. Karathanasis. Nanoscale 9 (2017) 9659-9667 | PubMed        

Vascular targeting of nanoparticles for molecular imaging of diseased endothelium

P.U. Atukorale, G. Covarrubias, L. Bauer, E. Karathanasis. Advanced Drug Delivery Reviews 113 (2017) 141-156 | PubMed        

Crossing the barrier: Treatment of brain tumors using nanochain particles

K.B. Ghaghada, E. Karathanasis. WIREs Nanomedicine & Nanobiotechnology 8 (2016) 678-695 | PubMed 

Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis

E. Doolittle, P.M. Peiris, G. Doron, A. Goldberg, S. Tucci, S. Rao, S. Shah, M. Sylvestre, P. Govender, O. Turan, W.P. Schiemann, Z. Lee, E. Karathanasis. ACS Nano 9(8) (2015) 8012-8021 | PubMed

Vascular targeting of a gold nanoparticle to breast cancer metastasis

P.M. Peiris, P. Deb, E. Doolittle, G. Doron, A. Goldberg, P. Govender, S. Shah, S. Rao, S. Carbone, T. Cotey, M. Sylvestre, S. Singh, W.P. Schiemann, Z. Lee, E. Karathanasis. Journal of Pharmaceutical Sciences 104(8) (2015) 2600-2610 | PubMed

Treatment of invasive brain tumors using a chain-like nanoparticle

P.M. Peiris, A. Abramowski, J. Mcginnity, E. Doolittle, R. Toy, R. Gopalakrishnan, S. Shah, L. Bauer, K.B. Ghaghada, C. Hoimes, S. Brady-Kalnay, J.P. Basilion, M.A. Griswold, E. Karathanasis. Cancer Research  75(7) (2015) 1356–1365 | PubMed        

Targeted nanotechnology for cancer imaging

 R. Toy, L. Bauer, C. Hoimes, K.B. Ghaghada, E. Karathanasis. Advanced Drug Delivery Reviews  76 (2014) 79-97 | PubMed        

Shaping cancer nanomedicine: The effect of particle shape on the in vivo journey of nanoparticles

R. Toy, P.M. Peiris, K.B. Ghaghada, E. Karathanasis. Nanomedicine (Lond) 9(1) (2014) 121-134 | PubMed

Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle

P.M. Peiris, R. Toy, A. Abramowski, P. Vicente, S. Tucci, L. Bauer, A. Mayer, M. Tam, E. Doolittle, J. Pansky, E. Tran, D. Lin, W.P. Schiemann, K.B. Ghaghada, M.A. Griswold, E. Karathanasis. Journal of Controlled Release 173 (2014) 51-59 | PubMed | *cover and featured article       

On-command drug release from nanochains inhibits growth of breast tumors

P.M. Peiris, M. Tam, P. Vicente, A. Abramowski, R. Toy, L. Bauer, A. Mayer, J. Pansky, E. Doolittle, S. Tucci, E. Schmidt, C. Shoup, S. Rao, K. Murray, R. Gopalakrishnan, R.A. Keri, J.P. Basilion, M.A. Griswold, E. Karathanasis. Pharmaceutical Research 31(6) (2014) 1460-1468 | PubMed        

Multimodal in vivo imaging exposes the voyage of nanoparticles in tumor microcirculation

R. Toy, E. Hayden, A. Camann, Z. Berman, P. Vicente, E. Tran, J. Meyers, J. Pansky, P. Peiris, H. Wu, A. Exner, D. Wilson, K. Ghaghada, E. Karathanasis. ACS Nano 7(4) (2013) 3118-3129 | PubMed        

Enhanced delivery of Chemotherapy to tumors using a multi-component nanochain with radiofrequency-tunable drug release

P. Peiris, L. Bauer, R. Toy, E. Tran, J. Pansky, E. Doolittle, E. Schmidt, E. Hayden, A. Mayer, R. Keri, M. Griswold, E. Karathanasis. ACS Nano 6(5) (2012) 4157-4168 | PubMed        

Imaging metastasis using an integrin-targeting chain-shaped nanoparticle

P. Peiris, R. Toy, E. Doolittle, J. Pansky, A. Abramowski, M. Tam, P. Vicente, E. Tran, E. Hayden, A. Camann, A. Mayer, B. Erokwu, Z. Berman, D. Wilson, H. Baskaran, C. Flask, R. Keri, E. Karathanasis. ACS Nano 6(10) (2012) 8783-8795 | PubMed        

High-resolution CT vascular imaging using blood pool contrast agents

A.V. Annapragada, E. Hoffman, A. Divekar, E. Karathanasis, K.B. Ghaghada. Methodist Debakey Cardiovasc J 8(1) (2012) 18-22 | PubMed

The effects of particle size, shape and density on margination of nanoparticles in microcirculation

R. Toy, E. Hayden, C. Shoup, H. Baskaran, E. Karathanasis. Nanotechnology 22(2011) 115101 (9pp) | PubMed     

Is nanomedicine still promising?

P.M. Peiris, E. Karathanasis. Oncotarget 2(6) (2011) 430-432 | PubMed         

Assembly of linear nano-chains from nanospheres with asymmetric surface chemistry

P.M. Peiris, E. Schmidt, M. Calabrese, E. Karathanasis. PLoS ONE 6(1) (2011) e15927 | PubMed

Selective targeting of nanocarriers to neutrophils and monocytes

E. Karathanasis, C.M. Geigerman, C.A. Parkos, L. Chan, R.V. Bellamkonda, D.L. Jaye. Annals of Biomedical Engineering 37(10) (2009) 1984-1992 | PubMed

Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers

E. Karathanasis, L. Chan, L. Karumbaiah, , K. McNeeley, C.J. D'Orsi, A.V. Annapragada, I. Sechopoulos, R.V. Bellamkonda. PLoS ONE 4(6) (2009) e5843 | PubMed

Masking and triggered umasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors

K. McNeeley, E. Karathanasis, A.V. Annapragada, R.V. Bellamkonda. Biomaterials (2009) 30(23-24) 3986-3995 | PubMed

Imaging nanoprobe for prediction of nanoparticle chemotherapy using mammography 

E. Karathanasis, S. Suryanarayanan, S.R. Balusu, K. McNeeley, I. Sechopoulos, A. Karellas, A.V. Annapragada, R.V. Bellamkonda. Radiology 250(2) (2009) 398-406 | PubMed

MRI mediated, non-invasive tracking of intratumoral distribution of nanocarriers in rat glioma

E. Karathanasis, J. Park, A. Agarwal, V. Patel, F. Zhao, A.V. Annapragada, X. Hu, R.V. Bellamkonda. Nanotechnology 19 315101 (9pp) 2008 | PubMed

Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy

E. Karathanasis, L. Chan, S.R. Balusu, C.J. D?Orsi, A.V. Annapragada, I. Sechopoulos, R.V. Bellamkonda. Biomaterials 29(36) (2008) 4815-4822 | PubMed

Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats 

E. Karathanasis, R. Bhavane, A.V. Annapragada. International Journal of Nanomedicine 2(3) (2007) 501-513 | PubMed

Triggered release of ciprofloxacin from nanostructured agglomerated vesicles 

R. Bhavane, E. Karathanasis, A.V. Annapragada. International Journal of Nanomedicine 2(3) (2007) 407-418 | PubMed

Triggered release of inhaled insulin from the agglomerated vesicles: Pharmacodynamic studies in rats 

E. Karathanasis, R. Bhavane, A.V. Annapragada. Journal of Controlled Release 113(2) (2006) 117-127 | PubMed

Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery 

E. Karathanasis, A. Ayyagari, R. Bhavane, R. Bellamkonda, A.V. Annapragada. Journal of Controlled Release 103(1) (2005) 159-175 | PubMed

Agglomerated Vesicle Technology: A new class of particles for controlled and modulated pulmonary drug delivery 

R. Bhavane, E. Karathanasis, A.V. Annapragada. Journal of Controlled Release 93(1) (2003) 15-28 | PubMed